Artificial intelligence-assisted ultrasound image analysis to discriminate early breast cancer in Chinese population: a retrospective, multicentre, cohort study

作者：Jianwei Liao, Yu Gui, Zhilin Li, Zijian Deng, Xian-Feng Han, Huanhuan Tian, Li Cai, Xingyu Liu, Chengyong Tang, Jia Liu, Wei Ya, Lan Hu, Fengling Niu, Jing Liu, Xi Yang, Shichao Li, Xiang Cui, Xin Wu, Qingqiu Chen, Andi Wan, Jun Jiang, Yi Zhang, Xiangdong Luo, Peng Wang, Zhigang Cai, Li Chen · 发表于：EClinicalMedicine · 年份：2023 · DOI：10.1016/j.eclinm.2023.102001 · 被引用次数：36 · 研究领域：Breast Lesions and Carcinomas、AI in cancer detection、Breast Cancer Treatment Studies

Background: Early diagnosis of breast cancer has always been a difficult clinical challenge. We developed a deep-learning model EDL-BC to discriminate early breast cancer with ultrasound (US) benign findings. This study aimed to investigate how the EDL-BC model could help radiologists improve the detection rate of early breast cancer while reducing misdiagnosis. Methods: In this retrospective, multicentre cohort study, we developed an ensemble deep learning model called EDL-BC based on deep convolutional neural networks. The EDL-BC model was trained and internally validated on B-mode and color Doppler US image of 7955 lesions from 6795 patients between January 1, 2015 and December 31, 2021 in the First Affiliated Hospital of Army Medical University (SW), Chongqing, China. The model was assessed by internal and external validations, and outperformed radiologists. The model performance was validated in two independent external validation cohorts included 448 lesions from 391 patients between January 1 to December 31, 2021 in the Tangshan People's Hospital (TS), Chongqing, China, and 245 lesions from 235 patients between January 1 to December 31, 2021 in the Dazu People's Hospital (DZ), Chongqing, China. All lesions in the training and total validation cohort were US benign findings during screening and biopsy-confirmed malignant, benign, and benign with 3-year follow-up records. Six radiologists performed the clinical diagnostic performance of EDL-BC, and six radiologists indep...