Catalytic Decarboxylative Radical Sulfinylation

作者：Shi-Hui He, Guang-Le Chen, Xing-Yu Gong, Gui‐Zhen Ao, Feng Liu · 发表于：The Journal of Organic Chemistry · 年份：2023 · DOI：10.1021/acs.joc.2c03051 · 被引用次数：18 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Radical Photochemical Reactions

Sulfoxides are ubiquitous in both naturally and synthetically bioactive molecules. We report herein a redox-neutral and mild approach for radical sulfinylation of redox-active esters via dual photoredox and copper catalysis, furnishing a series of functionalized sulfoxides. The reaction could accommodate a range of tertiary, secondary, and primary carboxylic acids, as well as exhibit wide functional group compatibility. The chemistry features a high degree of practicality, is scalable, and allows late-stage modification of bioactive pharmaceuticals.