A Novel Approach to α‐Arylacetonitrile Skeletons via para‐Selective Alkylation of Protected Anilines

作者：Zefeng Deng, Wei‐Tai Fan, Jian Liu, Guangliang Tu, Pengcheng Huang, Xu Xu, Jie Tan, Shun‐Jun Ji, Yingsheng Zhao · 发表于：Chemistry - A European Journal · 年份：2023 · DOI：10.1002/chem.202300905 · 被引用次数：9 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Asymmetric Hydrogenation and Catalysis

A ruthenium-catalyzed para-selective alkylation of protected anilines to construct α-arylacetonitrile skeletons has been reported. We firstly disclosed the ethyl 2-bromo-2-cyanopropanoate was an effective alkylating reagent in ruthenmuim-catalyzed remote-selective C-H functionalization. A wide variety of α-arylacetonitrile skeletons can be directly obtained with moderate to good yields. Importantly, the products contain both nitrile and ester groups guaranteeing its direct transformation into other useful synthetic units, indicating the synthetic importance of this method.