Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation

作者：Li‐Juan Tang, Zhenghan Di, Jingfang Zhang, Feiying Yin, Lele Li, Li Zheng · 发表于：Nano Research · 年份：2023 · DOI：10.1007/s12274-023-5721-z · 被引用次数：12 · 研究领域：Dendrimers and Hyperbranched Polymers、Nanoplatforms for cancer theranostics、MicroRNA in disease regulation

Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable challenge. In this study, we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug delivery. The resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability, allowing for the combination of magnetic resonance imaging and anti-inflammatory therapy. In the case of osteoarthritis (OA), the metallo-nanodrugs remarkably alleviate synovial inflammation, preventing cartilage destruction and extracellular matrix loss. In addition, it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse model. This work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly.