Molecular mechanisms involved in regulating protein activity and biological function of MST3

作者：Jing Qiu, Junzhi Xiong, Lu Jiang, Xinmin Wang, Kebin Zhang, Hua Yu · 发表于：Cell Division · 年份：2023 · DOI：10.1186/s13008-023-00090-x · 被引用次数：8 · 研究领域：Hippo pathway signaling and YAP/TAZ、Microtubule and mitosis dynamics、Cancer-related Molecular Pathways

Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the mammalian STE20-like protein kinase family. MST3 is a pleiotropic protein that plays a critical role in regulating a variety of events, including apoptosis, immune response, metabolism, hypertension, tumor progression, and development of the central nervous system. The MST3-mediated regulation is intricately related to protein activity, post-translational modification, and subcellular location. Here, we review the recent progress on the regulatory mechanisms against MST3 and its-mediated control of disease progression.