Characterization of a robust mouse model of heart failure with preserved ejection fraction

作者：Dzmitry Matsiukevich, Attila Kovács, Tiandao Li, Kristen M. Kokkonen-Simon, Scot J. Matkovich, Sunday S. Oladipupo, David M. Ornitz · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2023 · DOI：10.1152/ajpheart.00038.2023 · 被引用次数：37 · 研究领域：Cardiovascular Function and Risk Factors、Receptor Mechanisms and Signaling、Adipose Tissue and Metabolism

Heart failure with preserved ejection fraction (HFpEF) is an emerging epidemic affecting up to half of patients with heart failure. Here we used a chronic angiotensin II/phenylephrine (ANG II/PE) infusion model and instituted an updated algorithm for HFpEF assessment. Given the simplicity in generating this model, it may become a useful tool for investigating pathogenic mechanisms, identification of diagnostic markers, and for drug discovery aimed at both prevention and treatment of HFpEF.