Structural and functional improvement of amygdala sub-regions in postpartum depression after acupuncture

作者：Xingxian Huang, Yuanyuan Zhuo, Xinru Wang, Jinping Xu, Zhuoxin Yang, Yumei Zhou, Hanqing Lv, Xiaoming Ma, Bin Yan, Hong Zhao, Haibo Yu · 发表于：Frontiers in Human Neuroscience · 年份：2023 · DOI：10.3389/fnhum.2023.1163746 · 被引用次数：13 · 研究领域：Functional Brain Connectivity Studies、Acupuncture Treatment Research Studies、Treatment of Major Depression

Objective This study aimed to analyze the changes in structure and function in amygdala sub-regions in patients with postpartum depression (PPD) before and after acupuncture. Methods A total of 52 patients with PPD (All-PPD group) were included in this trial, 22 of which completed 8 weeks of acupuncture treatment (Acu-PPD group). An age-matched control group of 24 healthy postpartum women (HPW) from the hospital and community were also included. Results from the 17-Hamilton Depression Scale (17-HAMD) and the Edinburgh Postnatal Depression Scale (EPDS) were evaluated, and resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed at baseline and after the acupuncture treatment. Sub-regions of the amygdala were used as seed regions to measure gray matter volume (GMV) and analyzed for resting-state functional connectivity (RSFC) values separately. Finally, correlation analyses were performed on all patients with PPD to evaluate association values between the clinical scale scores, GMV, and RSFC values, while controlling for age and education. Pearson's correlation analyses were conducted to investigate the relevance between GMV and RSFC values of brain regions that differed before and after acupuncture treatment and clinical scale scores in Acu-PPD patients. Results The HAMD scores for Acu-PPD were reduced after acupuncture treatment ( P < 0.05), suggesting the positive effects of acupuncture on depression symptoms. Structurally, the All-PPD group ...