The pharmacology and mechanisms of traditional Chinese medicine in promoting liver regeneration: A new therapeutic option

作者：Jiating Ma, Shuang Xia, Bikui Zhang, Fen Luo, Lin Guo, Yan Yang, Hui Gong, Miao Yan · 发表于：Phytomedicine · 年份：2023 · DOI：10.1016/j.phymed.2023.154893 · 被引用次数：17 · 研究领域：Liver physiology and pathology、Hippo pathway signaling and YAP/TAZ、Drug-Induced Hepatotoxicity and Protection

BACKGROUND: The liver is renowned for its remarkable regenerative capacity to restore its structure, size and function after various types of liver injury. However, in patients with end-stage liver disease, the regenerative capacity is inhibited and liver transplantation is the only option. Considering the limitations of liver transplantation, promoting liver regeneration is suggested as a new therapeutic strategy for liver disease. Traditional Chinese medicine (TCM) has a long history of preventing and treating various liver diseases, and some of them have been proven to be effective in promoting liver regeneration, suggesting the therapeutic potential in liver diseases. PURPOSE: This review aims to summarize the molecular mechanisms of liver regeneration and the pro-regenerative activity and mechanism of TCM formulas, extracts and active ingredients. METHODS: We conducted a systematic search in PubMed, Web of Science and the Cochrane Library databases using "TCM", "liver regeneration" or their synonyms as keywords, and classified and summarized the retrieved literature. The PRISMA guidelines were followed. RESULTS: Forty-one research articles met the themes of this review and previous critical studies were also reviewed to provide essential background information. Current evidences indicate that various TCM formulas, extracts and active ingredients have the effect on stimulating liver regeneration through modulating JAK/STAT, Hippo, PI3K/Akt and other signaling pathways. Be...