Auditory P300 in individuals with high schizotypy: associations of schizotypal traits with amplitude and latency under different oddball conditions

作者：Jue Deng, Si-Wei Chen, Yuanhua Ou, Yuanjun Zhang, Ziyue Lin, Yane Shen, Yiduo Ye · 发表于：Frontiers in Human Neuroscience · 年份：2023 · DOI：10.3389/fnhum.2023.1107858 · 被引用次数：4 · 研究领域：Schizophrenia research and treatment、Neuroscience and Music Perception、Cognitive Functions and Memory

Background The aim of this study was to compare the characteristics of auditory P300 between non-clinical individuals with high and low schizotypal traits, and investigate the relationship between schizotypy and P300 under various oddball conditions. Methods An extreme-group design was adopted. After screening 1,519 young adults using the Schizotypal Personality Questionnaire (SPQ), sixty-three participants were chosen and divided into two groups (schizotypy group: 31 participants; control group: 32 participants). Basic demographic information was assessed and matched between groups. Depression and anxiety indexes were evaluated and controlled. The P300 component was evoked by an auditory oddball paradigm with different frequencies and durations. Results (1) The duration P300 amplitude at PZ site was significantly weaker in the schizotypy group than in the control group [ F (1,54) = 7.455, p = 0.009, η p 2 = 0.121]. (2) In the schizotypy group, the latency of frequency P300 at PZ site under large-variant oddball condition was significantly correlated with total SPQ scores ( r p = 0.451, p = 0.018) and disorganized dimension scores ( r p = 0.381, p = 0.050). (3) In the control group, significantly negative correlations was found between the negative dimension score of SPQ and the frequency P300 amplitudes under small variant condition (PZ: r p = −0.393, p = 0.043; CPZ: r p = −0.406, p = 0.035). In addition, a significant negative relationship was found between disorganized dim...