Perineural invasion affects prognosis of patients undergoing colorectal cancer surgery: a propensity score matching analysis

作者：Le Qin, Yixin Heng, Shenghe Deng, Junnan Gu, Fuwei Mao, Yifan Xue, Zhenxing Jiang, Jun Wang, Denglong Cheng, Ke Wu, Yinghao Cao, Kailin Cai · 发表于：BMC Cancer · 年份：2023 · DOI：10.1186/s12885-023-10936-w · 被引用次数：25 · 研究领域：Colorectal Cancer Surgical Treatments、Cancer, Stress, Anesthesia, and Immune Response、Intraperitoneal and Appendiceal Malignancies

BACKGROUND: Tumour perineural invasion (PNI) is a predictor of poor prognosis, but its effect on the prognosis of patients with colorectal cancer (CRC) has not yet been elucidated. METHODS: This retrospective study used propensity score matching (PSM). The clinical case data of 1470 patients with surgically treated stage I-IV CRC at Wuhan Union Hospital were collected. PSM was used to analyse and compare the clinicopathological characteristics, perioperative outcomes, and long-term prognostic outcomes of the PNI(+) and PNI(-) groups. The factors influencing prognosis were screened using Cox univariate and multivariate analyses. RESULTS: After PSM, 548 patients were included in the study (n = 274 in each group). Multifactorial analysis showed that neurological invasion was an independent prognostic factor affecting patients' OS and DFS (hazard ratio [HR], 1.881; 95% confidence interval [CI], 1.35-2.62; P = 0.0001; HR, 1.809; 95% CI, 1.353-2.419; P < 0.001). Compared to PNI(+) patients without chemotherapy, those who received chemotherapy had a significant improvement in OS (P < 0.01). The AUROC curve of OS in the PNI(+) subgroup (0.802) was higher than that after PSM (0.743), while that of DFS in the PNI(+) subgroup (0.746) was higher than that after PSM (0.706). The independent predictors of PNI(+) could better predict the prognosis and survival of patients with PNI(+). CONCLUSIONS: PNI significantly affects the long-term survival and prognosis of patients with CRC undergoing...