Erythromycin resistance of clinical Campylobacter jejuni and Campylobacter coli in Shanghai, China

作者：Fen Gao, Lihong Tu, Mingliang Chen, Mingliang Chen, Hong-You Chen, Xi Zhang, Yuan Zhuang, Jiayuan Luo, Min Chen, Min Chen · 发表于：Frontiers in Microbiology · 年份：2023 · DOI：10.3389/fmicb.2023.1145581 · 被引用次数：27 · 研究领域：Salmonella and Campylobacter epidemiology、Vibrio bacteria research studies、Antibiotic Resistance in Bacteria

Campylobacter species are zoonotic pathogens, as well as the prevalent cause of foodborne bacterial gastroenteritis. The spread of antimicrobial-resistant strains poses a serious threat to global public health and attracts attention worldwide, but information about clinical Campylobacter is relatively limited compared to isolates from food and animals. The current study illustrated the prevalence and antimicrobial resistance profiles of Campylobacter jejuni and Campylobacter coli isolates collected from a consecutive surveillance program between 2012 and 2019 in Shanghai, China, using antimicrobial susceptibility testing and whole-genome sequencing. Among the 891 Campylobacter strains (761 C. jejuni and 130 C. coli ) isolates collected, high portions above 90% of resistance to ciprofloxacin, nalidixic acid, and tetracycline were observed for both C. jejuni and C. coli . The most common MDR profiles represented by C. jejuni and C. coli were combination of ciprofloxacin, tetracycline, florfenicol and nalidixic acid (5.39%), and azithromycin, ciprofloxacin, erythromycin, gentamicin, tetracycline, clindamycin, nalidixic acid (28.46%), respectively. The erythromycin resistance of C. coli (59.23%) is higher than C. jejuni (2.50%). A total of 76 erythromycin resistant isolates (16 C. jejuni and 60 C. coli ) were sequenced using Illumina platform for determining the genotypes, antimicrobial resistance patterns and phylogeny analysis. Multilocus sequence typing (MLST) analysis showed ...