Dual-stream cortical pathways mediate sensory prediction

作者：Qian Chu, Ou Ma, Yuqi Hang, Xing Tian · 发表于：Cerebral Cortex · 年份：2023 · DOI：10.1093/cercor/bhad168 · 被引用次数：10 · 研究领域：Neural dynamics and brain function、Functional Brain Connectivity Studies、Neural and Behavioral Psychology Studies

Predictions are constantly generated from diverse sources to optimize cognitive functions in the ever-changing environment. However, the neural origin and generation process of top-down induced prediction remain elusive. We hypothesized that motor-based and memory-based predictions are mediated by distinct descending networks from motor and memory systems to the sensory cortices. Using functional magnetic resonance imaging (fMRI) and a dual imagery paradigm, we found that motor and memory upstream systems activated the auditory cortex in a content-specific manner. Moreover, the inferior and posterior parts of the parietal lobe differentially relayed predictive signals in motor-to-sensory and memory-to-sensory networks. Dynamic causal modeling of directed connectivity revealed selective enabling and modulation of connections that mediate top-down sensory prediction and ground the distinctive neurocognitive basis of predictive processing.