Identification of a Linear B Cell Epitope on p54 of African Swine Fever Virus Using Nanobodies as a Novel Tool

作者：Huijun Zhao, Gaijie Wang, Haoxin Dong, Shuya Wu, Yongkun Du, Bo Wan, Pengchao Ji, Yanan Wu, Dawei Jiang, Guoqing Zhuang, Hong Duan, Gaiping Zhang, Angke Zhang · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.03362-22 · 被引用次数：18 · 研究领域：Animal Disease Management and Epidemiology、Vector-Borne Animal Diseases、Viral gastroenteritis research and epidemiology

, among different ASFV strains, and it can induce humoral immune responses in pigs. This is the first report using virus-specific nanobodies as a tool to identify some special epitopes that cannot be recognized by conventional monoclonal antibodies. This study opens up nanobodies as a new tool for identifying epitopes and also provides a theoretical basis for understanding p54-induced neutralizing antibodies.