The intestinal mucosal barrier – A key player in rheumatoid arthritis?

作者：Jing Li, Nini Jia, Mengyao Cui, Yaqing Li, Xiang Li, Xiaoqin Chu · 发表于：Clinical Anatomy · 年份：2023 · DOI：10.1002/ca.24055 · 被引用次数：7 · 研究领域：Inflammatory Bowel Disease、Pharmacological Effects of Natural Compounds、Gut microbiota and health

Rheumatoid arthritis (RA) is a recurrent chronic autoimmune disease, which is not only difficult to treat, but also has a great adverse impact on the physical and mental health of patients. The intestinal mucosa barrier has some relationship with RA and it consists of mechanical barrier, chemical barrier, immune barrier, and microflora barrier. It is a dynamic system that contributes to the stability of the intestinal environment by regulating the absorption of relevant substances from the lumen into the circulation, while limiting the passage of harmful substances. This article summarizes the connection between the intestinal mucosa barrier and RA, and proposes the role of relevant Chinese medicines on RA from the point of improving barriers, to provide new perspectives on the pathogenesis and therapeutic strategies of RA.