NAD+ metabolism-based immunoregulation and therapeutic potential

作者：Jiankai Fang, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Shisong Liu, Chao Feng, Yuyi Han, Peishan Li, Yufang Shi, Changshun Shao · 发表于：Cell & Bioscience · 年份：2023 · DOI：10.1186/s13578-023-01031-5 · 被引用次数：49 · 研究领域：Sirtuins and Resveratrol in Medicine、Calcium signaling and nucleotide metabolism、PARP inhibition in cancer therapy

Abstract Nicotinamide adenine dinucleotide (NAD + ) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD + -dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD + metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD + bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD + biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD + research in the development of therapeutics for inflammatory diseases, such as COVID-19.