Effects of first‐line antidiabetic drugs on the improvement of arterial stiffness: A Bayesian network meta‐analysis

作者：Jincheng Wang, Yuhan Wang, Yueheng Wang, Yu Li, Jiamei Zhang, Han Zhang, Xiaomin Fu, Zhiqin Guo, Ying Yang, Kaining Kang, Wei Zhang, Li Tian, Yanqiang Wu, Shuanli Xin, Hongzhou Liu · 发表于：Journal of Diabetes · 年份：2023 · DOI：10.1111/1753-0407.13405 · 被引用次数：19 · 研究领域：Cardiovascular Health and Disease Prevention、Blood Pressure and Hypertension Studies、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: Changes in vascular function are closely associated with the development of cardiovascular disease (CVD). Pulse wave velocity (PWV) is a potential indicator of vascular dysfunction; it allows noninvasive assessment of arterial stiffness. Currently, evidence for the effects of different classes of antidiabetic drugs on arterial stiffness remains limited. In this study, a network meta-analysis (NMA) was performed to explore the associations between changes in arterial stiffness and first-line antidiabetic drugs by evaluating PWV in patients with different metabolic abnormalities. METHODS: We systematically searched several electronic databases for randomized controlled trials (RCTs) published from inception until 25 August 2022, without language restrictions. The primary outcome was the change in PWV (ΔPWV) in all included studies; subgroup analysis was performed for patients with abnormal glucose metabolism, including prediabetes and diabetes mellitus. NMA was performed to calculate the mean differences (MDs) with 95% confidence intervals (CIs) as effect sizes to evaluate the ΔPWV. RESULTS: Among the 2257 candidate articles identified in the initial search, 18 RCTs were eventually included in the analysis. In all studies, two classes of new antidiabetic drugs, glucagon-like peptide-1 receptor (GLP-1R) agonists and sSodium-glucose co-transporter 2 (SGLT-2) inhibitors, improved arterial stiffness by decreasing PWV compared with placebo (MD = -1.11, 95% CI: -1.94 to 0...