Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

作者：Piotr Jahołkowski, Alexey Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora R. Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen · 发表于：JAMA Psychiatry · 年份：2023 · DOI：10.1001/jamapsychiatry.2023.1137 · 被引用次数：32 · 研究领域：Menstrual Health and Disorders、Folate and B Vitamins Research、Biochemical effects in animals

Importance: Premenstrual disorders are heritable, clinically heterogenous, with a range of affective spectrum comorbidities. It is unclear whether genetic predispositions to affective spectrum disorders or other major psychiatric disorders are associated with symptoms of premenstrual disorders. Objective: To assesss whether symptoms of premenstrual disorders are associated with the genetic liability for major psychiatric disorders, as indexed by polygenic risk scores (PRSs). Design, Setting, and Participants: Women from the Norwegian Mother, Father and Child Cohort Study were included in this genetic association study. PRSs were used to determine whether genetic liability for major depression, bipolar disorder, schizophrenia, attention-deficit/hyperactivity disorder, and autism spectrum disorder were associated with the symptoms of premenstrual disorders, using the PRS for height as a somatic comparator. The sample was recruited across Norway between June 1999 and December 2008, and analyses were performed from July 1 to October 14, 2022. Main Outcomes and Measures: The symptoms of premenstrual disorders were assessed at recruitment at week 15 of pregnancy with self-reported severity of depression and irritability before menstruation. Logistic regression was applied to test for the association between the presence of premenstrual disorder symptoms and the PRSs for major psychiatric disorders. Results: The mean (SD) age of 56 725 women included in the study was 29.0 (4.6) year...