Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

作者：Changzhen Wang, Min-Ge Wang, Yue-Fei Chu, Ruan-Yang Sun, Jianguo Li, Xianan Li, Jian Sun, Ya-Hong Liu, Yu‐Feng Zhou, Xiao‐Ping Liao · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.00309-23 · 被引用次数：26 · 研究领域：Streptococcal Infections and Treatments、Antimicrobial Resistance in Staphylococcus、Neonatal and Maternal Infections

S. suis is a serious zoonotic pathogen. In this study, we investigated the epidemiological and molecular characteristics of 96 S. suis isolates from 10 different provinces of China from 2008 to 2019. A subset of these isolates (10) carried ICEs that were able to be horizontally transferred among isolates of different S. suis serotypes. A mouse thigh infection model revealed that ICE-facilitated ARG transfer promoted resistance development. S. suis requires continuous monitoring, especially for the presence of ICEs and associated ARGs that can be transferred via conjugation.