Flexible, high‐resolution cortical arrays with large coverage capture microscale high‐frequency oscillations in patients with epilepsy

作者：Katrina Barth, James Sun, Chia‐Han Chiang, Shaoyu Qiao, Charles Wang, Shervin Rahimpour, Michael Trumpis, Suseendrakumar Duraivel, Agrita Dubey, Katie Wingel, Alex Efstathios Voinas, Breonna Ferrentino, Werner Doyle, Derek G. Southwell, Michael M. Haglund, Matthew Vestal, Stephen C. Harward, Florian Solzbacher, Sasha Devore, Orrin Devinsky, Daniel Friedman, Bijan Pesaran, Saurabh R. Sinha, Gregory B. Cogan, Justin A. Blanco, Jonathan Viventi · 发表于：Epilepsia · 年份：2023 · DOI：10.1111/epi.17642 · 被引用次数：24 · 研究领域：EEG and Brain-Computer Interfaces、Liquid Crystal Research Advancements、Epilepsy research and treatment

OBJECTIVE: Effective surgical treatment of drug-resistant epilepsy depends on accurate localization of the epileptogenic zone (EZ). High-frequency oscillations (HFOs) are potential biomarkers of the EZ. Previous research has shown that HFOs often occur within submillimeter areas of brain tissue and that the coarse spatial sampling of clinical intracranial electrode arrays may limit the accurate capture of HFO activity. In this study, we sought to characterize microscale HFO activity captured on thin, flexible microelectrocorticographic (μECoG) arrays, which provide high spatial resolution over large cortical surface areas. METHODS: We used novel liquid crystal polymer thin-film μECoG arrays (.76-1.72-mm intercontact spacing) to capture HFOs in eight intraoperative recordings from seven patients with epilepsy. We identified ripple (80-250 Hz) and fast ripple (250-600 Hz) HFOs using a common energy thresholding detection algorithm along with two stages of artifact rejection. We visualized microscale subregions of HFO activity using spatial maps of HFO rate, signal-to-noise ratio, and mean peak frequency. We quantified the spatial extent of HFO events by measuring covariance between detected HFOs and surrounding activity. We also compared HFO detection rates on microcontacts to simulated macrocontacts by spatially averaging data. RESULTS: We found visually delineable subregions of elevated HFO activity within each μECoG recording. Forty-seven percent of HFOs occurred on single 2...