Efficacy and safety of human umbilical cord-derived mesenchymal stem cells for COVID-19 pneumonia: a meta-analysis of randomized controlled trials

作者：Qinxue Liu, Fengjie Ma, Yizhi Zhong, Gaojian Wang, Li Hu, Yaping Zhang, Junran Xie · 发表于：Stem Cell Research & Therapy · 年份：2023 · DOI：10.1186/s13287-023-03286-8 · 被引用次数：16 · 研究领域：Mesenchymal stem cell research、COVID-19 Clinical Research Studies、Dermatological and COVID-19 studies

Abstract Background Elevated levels of inflammatory factors are associated with poor prognosis in coronavirus disease-19 (COVID-19). However, mesenchymal stem cells (MSCs) have immunomodulatory functions. Accordingly, this meta-analysis aimed to determine the efficacy and safety of MSC-based therapy in patients with COVID-19 pneumonia. Methods Online global databases were used to find relevant studies. Two independent researchers then selected and evaluated the studies for suitability while the Cochrane risk of bias tool determined the quality of all articles and Cochran's Q test and I 2 index assessed the degree of heterogeneity in the principal studies. Statistical analysis was performed using Review Manager software, and the effect of each study on the overall estimate was evaluated by sensitivity analysis. Results Seven studies were included in the meta-analysis, and all MSCs used in the trials were acquired from the umbilical cord. The results of these studies (n = 328) indicated that patients with COVID-19 pneumonia who received MSCs had a 0.58 risk of death compared with controls (95% CI = 0.38, 0.87; P = 0.53; I 2 = 0%). In terms of inflammatory biomarkers, MSCs reduced the levels of C-reactive protein (n = 88; MD = − 32.49; 95% CI = − 48.43, − 16.56; P = 0.46; I 2 = 0%) and interferon-gamma (n = 44; SMD = − 1.23; 95% CI = − 1.89, − 0.57; P = 0.37; I 2 = 0%) in severe COVID-19 patients but had no significant effect on interleukin-6 (n = 185; MD = − 0.75; 95% CI = − 7....