YAP promotes AP-1 expression in tubular epithelial cells in the kidney

作者：Yang Liu, Chunhua Xu, Jinhong Li, Yu Zhang, Xiaohua Wang, Yang Wang, Jinzhong Qin, Zhihua Zheng, Yin Xia · 发表于：American Journal of Physiology-Renal Physiology · 年份：2023 · DOI：10.1152/ajprenal.00246.2022 · 被引用次数：11 · 研究领域：Hippo pathway signaling and YAP/TAZ、Genital Health and Disease

Yes-associated protein (YAP) activation leads to tubular injury, renal inflammation, and fibrosis, but the underlying mechanisms are not fully understood. We now provide genetic evidence that YAP promotes activator protein-1 expression and that Fosl1 is the primary target of YAP in renal tubular cells.