High-Sensitivity Troponins and Subclinical Coronary Atherosclerosis Evaluated by Coronary Calcium Score Among Older Asians Living With Well-Controlled Human Immunodeficiency Virus

作者：Pairoj Chattranukulchai, Manasawee Vassara, Sarawut Siwamogsatham, Wacin Buddhari, Monravee Tumkosit, Chutitorn Ketloy, Prapimporn Chattranukulchai Shantavasinkul, Tanakorn Apornpong, Hay Mar Su Lwin, Stephen J. Kerr, Smonporn Boonyaratavej, Anchalee Avihingsanon, HIV-NAT 006/207 study team, Praphan Phanuphak, Kiat Ruxrungtham, Anchalee Avihingsanon, Sivaporn Gatechompol, Hay Mar Su Lwin, Win Min Han, Kobchoke Woratanarat, Akarin Hiransuthikul, Thanathip Wichiansan, Jedsadakorn Boonrungsirisap, Stephen J. Kerr, Tanakorn Apornpong, Jiratchaya Sophonphan, Supalak Phonphithak, Chuleeporn Wongvoranet, Prachya Chaiyahong, Jaravee Jirapasiri, Paritaporn Sarachat, Nattawadee Setta, Khuanruan Supakawee, Supaporn Duchchanutat, Chavalun Ruengpanyathip, Chowalit Phadungphon, Orathai Treepattanasuwan, Theeradej Boonmangum, Plengsri Lertarrom, Anuntaya Uanithirat, Sararut Chanthaburanun, Anongnart Anuchadbut, Piyaporn Tanjedrew, Ratree Longcharaen, Niti Wongthai, Threepol Sattong, Sasiwimol Ubolyam, Apicha Mahanontharit, Bunruan Sopa, Umaporn Chobkarching, Channuwat Bouko, Nuchtida Phongam, Thatri Iampornsin, Theera Dalodom, Apichaya Khlaiphuengsin, Sasitorn Plakunmonthon, Kesdao Nanthapisal, Umaporn Methanggool, Chornarin Thangjitthanom, Kanokon Sirichumpa, Jutharos Chobkarjing, Adisak Jamrasrak, Natthapa Pitayanon, Engon Phuengchangam, Pairoj Chattranukulchai, Manasawee Vassara, Wacin Buddhari, Smonporn Boonyaratavej Songmuang, Weerayut Thimaporn, Sarawut Siwamogsatham, Monravee Tumkosit, Chutitorn Ketloy, Prapimporn Chattranukulchai Shantavasinkul, Sarat Sunthomyothin, Lalita Wattanachanya, Tawachai Chaiwatanarat, Aurauma Chutinet, Pongpat Vongsayan, Jitrada Samajarn, Opass Putcharoen, Sudarat Satitthummanid, Aekarach Ariyachaipanich · 发表于：Open Forum Infectious Diseases · 年份：2023 · DOI：10.1093/ofid/ofad234 · 被引用次数：7 · 研究领域：Cardiac Valve Diseases and Treatments、Cardiac Imaging and Diagnostics、Infective Endocarditis Diagnosis and Management

Abstract Background Elevated levels of high-sensitivity cardiac troponin (hs-cTn) are suggestive of myocardial cell injury and coronary artery disease. We explored the association between hs-cTn and subclinical arteriosclerosis using coronary artery calcification (CAC) scoring among 337 virally suppressed patients with human immunodeficiency virus (HIV) who were ≥50 years old and without evidence of known coronary artery disease. Methods Noncontrast cardiac computed tomography and blood sampling for hs-cTn, both subunit I (hs-cTnI) and subunit T (hs-cTnT), were performed. The relationship between CAC (Agatston score) and serum hs-cTn levels was analyzed using Spearman correlation and logistic regression models. Results The patients, of whom 62% were male, had a median age of 54 years and had been on antiretroviral therapy for a median of 16 years; the CAC score was >0 in 50% of patients and ≥100 in 16%. Both hs-cTn concentrations were positively correlated with the Agatston score, with correlation coefficients of 0.28 and 0.27 (P < .001) for hs-cTnI and hs-cTnT, respectively. hs-cTnI and hs-cTnT concentrations of ≥4 and ≥5.3 pg/mL, respectively, provided the best performance for discriminating patients with Agatston scores ≥100, with a sensitivity and specificity of 76% and 60%, respectively, for hs-cTnI and 70% and 50% for hs-cTnT. In multivariable logistic regression analysis, each log unit increase in hs-cTnI level was independently associated with increased ...