Association between accelerometer-measured amplitude of rest–activity rhythm and future health risk: a prospective cohort study of the UK Biobank

作者：Hongliang Feng, Lulu Yang, Sizhi Ai, Yue Liu, Weijie Zhang, Binbin Lei, Jie Chen, Yaping Liu, Joey Wing Yan Chan, Ngan Yin Chan, Xiao Tan, Ningjian Wang, Christian Benedict, Fu‐Jun Jia, Yun Kwok Wing, Jihui Zhang · 发表于：The Lancet Healthy Longevity · 年份：2023 · DOI：10.1016/s2666-7568(23)00056-9 · 被引用次数：83 · 研究领域：Circadian rhythm and melatonin、Physical Activity and Health、Sleep and related disorders

BACKGROUND: The health effects of rest-activity rhythm are of major interest to public health, but its associations with health outcomes remain elusive. We aimed to examine the associations between accelerometer-measured rest-activity rhythm amplitude and health risks among the general UK population. METHODS: We did a prospective cohort analysis of UK Biobank participants aged 43-79 years with valid wrist-worn accelerometer data. Low rest-activity rhythm amplitude was defined as the first quintile of relative amplitude; all other quintiles were classified as high rest-activity rhythm amplitude. Outcomes of interest were defined using International Classification of Diseases 10th Revision codes and consisted of incident cancer and cardiovascular, infectious, respiratory, and digestive diseases, and all-cause and disease-specific (cardiovascular, cancer, and respiratory) mortality. Participants with a current diagnosis of any outcome of interest were excluded. We assessed the associations between decreased rest-activity rhythm amplitude and outcomes using Cox proportional hazards models. FINDINGS: Between June 1, 2013, and Dec 23, 2015, 103 682 participants with available raw accelerometer data were enrolled. 92 614 participants (52 219 [56·4%] women and 40 395 [42·6%] men) with a median age of 64 years (IQR 56-69) were recruited. Median follow-up was 6·4 years (IQR 5·8-6·9). Decreased rest-activity rhythm amplitude was significantly associated with increased incidence of cardi...