Rh(III)-Catalyzed Synthesis of Substituted Isoindoles through a Direct C–H Activation/[4 + 1] Annulation and Acyl Migration Cascade of Oxadiazolones with Diazo Compounds

作者：Xiaohao Yang, Hairu Ren, Shengbin Zhou, Chunpu Li, Chaoyi Liu, Yu Zhou, Guoxue He, Hong Liu · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c00547 · 被引用次数：15 · 研究领域：Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms、Synthesis and Catalytic Reactions

A Rh(III)-catalyzed C–H bond activation for the synthesis of fused 2 H -isoindole scaffolds from oxadiazolones with diazo compounds was developed. The reaction proceeded through C–H activation of oxadiazolones/[4 + 1] annulation, intramolecular cyclization, and an unusual acyl migration cascade to afford target scaffolds with good yields. These 2 H -isoindole derivatives could be further transformed into intriguing drug privileged scaffolds.