HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy

作者：Tianyuan Zhu, Wei Cao, Taisheng Li · 发表于：AIDS · 年份：2023 · DOI：10.1097/qad.0000000000003587 · 被引用次数：14 · 研究领域：HIV Research and Treatment、Immune Cell Function and Interaction、HIV/AIDS Research and Interventions

We studied the relationship between HIV DNA and CD8 + T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8 + T-cells and was positively correlated with total HIV DNA [odds ratio (OR) = 1.86, P = 0.028) during 8 years of suppressive antiretroviral therapy (ART). This study illustrated the long-term interplay between HIV DNA reservoir and host inflammatory state despite viral suppression.