The efficacy of low-intensity transcranial ultrasound stimulation on negative symptoms in schizophrenia: A double-blind, randomized sham-controlled study

作者：Zhaolin Zhai, Liyuan Ren, Zhenhua Song, Qiong Xiang, Kaiming Zhuo, Suzhen Zhang, Xuan Li, Yi Zhang, Xiong Jiao, Shanbao Tong, Junfeng Sun, Dengtang Liu · 发表于：Brain stimulation · 年份：2023 · DOI：10.1016/j.brs.2023.04.021 · 被引用次数：42 · 研究领域：Transcranial Magnetic Stimulation Studies、Migraine and Headache Studies、Pain Management and Treatment

Schizophrenia is a severe, chronic, and disabling mental disorder that is among the most economically catastrophic illnesses [1]. Negative symptoms are some of the core symptoms of schizophrenia that are poorly treated and severely interfere with the functional status [2]. Non-invasive brain stimulation (NIBS) has been extensively applied to investigate the negative symptoms in schizophrenia patients [2,3]. Along with the evidence-based guidelines reappraisal in 2020, TMS was downgraded from Level B (probable efficacy) to Level C (possible efficacy) on negative symptoms in schizophrenia [3].