The Alterations of Gut Microbiome and Lipid Metabolism in Patients with Spinal Muscular Atrophy

作者：Yijie Feng, Yiqin Cui, Jianing Jin, Siyi Huang, Jia Wei, Mei Yao, Dongming Zhou, Shanshan Mao · 发表于：Neurology and Therapy · 年份：2023 · DOI：10.1007/s40120-023-00477-6 · 被引用次数：28 · 研究领域：Neurogenetic and Muscular Disorders Research、Muscle Physiology and Disorders、Amyotrophic Lateral Sclerosis Research

INTRODUCTION: Spinal muscular atrophy (SMA) can cause multiple system dysfunction, especially lipid metabolic disorders, for which management strategies are currently lacking. Microbes are related to metabolism and the pathogenesis of neurological diseases. This study aimed to preliminarily explore the alterations in the gut microbiota in SMA and the potential relationship between altered microbiota and lipid metabolic disorders. METHODS: Fifteen patients with SMA and 17 gender- and age-matched healthy controls were enrolled in the study. Feces and fasting plasma samples were collected. 16S ribosomal RNA sequencing and nontargeted metabolomics analysis were performed to explore the correlation between microbiota and differential lipid metabolites. RESULTS: No significant difference was found in microbial diversity (α- and β-diversity) between the SMA and control groups, with both groups having a relatively similar community structure. However, compared to the control group, the SMA group showed an increased relative abundance of the genera Ruminiclostridium, Gordonibacter, Enorma, Lawsonella, Frisingicoccus, and Anaerofilum and a decreased abundance of the genera Catabacter, Howardella, Marine_Methylotrophic_Group_3, and Lachnospiraceae_AC2044_group. The concurrent metabolomic analysis showed that the SMA group had 56 different kinds of lipid metabolite levels than did the control group. Additionally, the Spearman correlation suggested a correlation between the altered differ...