A hypoxia-activatable theranostic agent with intrinsic endoplasmic reticulum affinity and type-I photosensitivity

作者：Junqing Zhang, Yongkang Zhang, Hao Zhang, Wenhao Zhai, Xiaoqian Shi, Changhua Li · 发表于：Journal of Materials Chemistry B · 年份：2023 · DOI：10.1039/d3tb00328k · 被引用次数：26 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Advanced Nanomaterials in Catalysis

applications. After intravenous administration to 4T1 tumor-bearing BALB/c mice, Im@NP demonstrated highly efficient imaging-guided PDT ablation of implanted tumors. This is because the delivered ERPSIm cargos of Im@NP are specifically activated in the hypoxic microenvironment of solid tumor, and the activated ERPS molecules have efficient ER-targeted type-I photosensitivity.