Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023)

作者：Xinyue Wang, Fanyan Meng, Xiang Li, Luxin Xue, Anni Chen, Yuling Qiu, Zhifan Zhang, Lin Li, Fengcen Liu, Yishan Li, Zhichen Sun, Yanhong Chu, Rui‐Hua Xu, Lixia Yu, Jie Shao, Manman Tian, Xiaoping Qian, Qin Liu, Baorui Liu, Rutian Li · 发表于：Advanced Science · 年份：2023 · DOI：10.1002/advs.202370074 · 被引用次数：1 · 研究领域：CAR-T cell therapy research、Graphene and Nanomaterials Applications

Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co-workers constructed gelatinase-responsive NanoSwitch to control the activation process of CAR-T cells, leading to on-site activation of CAR-T cells at the tumor region in a sustainable way. This platform has promising potential to prevent the main obstacles in the CAR-T therapy for solid tumors including cytokine-release syndrome and on-target/off-tumor toxicity.