Heparin Prowess: Favorable Vascular–Immune Reprogramming in Pancreatic Cancer

作者：Murray Korc · 发表于：Clinical Cancer Research · 年份：2023 · DOI：10.1158/1078-0432.ccr-23-0346 · 被引用次数：3 · 研究领域：Cancer Immunotherapy and Biomarkers、Immune cells in cancer、Immunotherapy and Immune Responses

Several approaches for overcoming immunotherapy resistance in pancreatic and colorectal cancer syngeneic models were assessed using heparin and immunotherapy. Beneficial responses were attributed to heparin-induced vascular normalization, ensuing CD8+ T-cell infiltration, and M1 macrophage polarization, suggesting the potential for heparin-anchored therapies in cold tumors such as pancreatic cancer. See related article by Wei et al., p. 2525.