Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI

作者：Dong Qiu, Wei Wang, Yanliang Mei, Hefei Tang, Ziyu Yuan, Peng Zhang, Yaqing Zhang, Xueying Yu, Chunqing Yang, Qun Wang, Yonggang Wang · 发表于：The Journal of Headache and Pain · 年份：2023 · DOI：10.1186/s10194-023-01581-6 · 被引用次数：20 · 研究领域：Migraine and Headache Studies、Functional Brain Connectivity Studies、Spatial Neglect and Hemispheric Dysfunction

BACKGROUND: New daily persistent headache (NDPH) is a rare but debilitating primary headache disorder that poses a significant burden on individuals and society. Despite its clinical importance, the underlying pathophysiological mechanisms of NDPH remain unclear. In this study, we aimed to investigate the brain structural changes and neural activity patterns in patients with NDPH using multimodal brain imaging analysis of structural magnetic resonance imaging (sMRI) combined with magnetoencephalography (MEG). METHODS: Twenty-eight patients with NDPH and 37 healthy controls (HCs) were recruited for this study, and their structural and resting-state data were collected by 3.0 Tesla MRI and MEG. We analyzed the brain morphology using voxel-based morphometry and source-based morphometry. In each brain region, MEG sensor signals from 1 to 200 Hz were analyzed using an adapted version of Welch's method. MEG source localization was conducted using the dynamic statistical parametric mapping, and the difference of source distribution between patients with NDPH and HCs was examined. RESULTS: Our results revealed significant differences in the regional grey matter volume, cortical thickness, and cortical surface area between the two groups. Specifically, compared with HCs, patients with NDPH showed a significant decrease in cortical thickness of the left rostral cortex in the middle frontal gyrus, decreased cortical surface area of the left fusiform gyrus, decreased grey matter volume o...