Dietary 5-demethylnobiletin prevents antibiotic-associated dysbiosis of gut microbiota and damage to the colonic barrier

作者：Minmin Zhan, Xinyan Liang, Jiaqi Chen, Xiaoshuang Yang, Yanhui Han, Chenxi Zhao, Jie Xiao, Yong Cao, Hang Xiao, Mingyue Song · 发表于：Food & Function · 年份：2023 · DOI：10.1039/d3fo00516j · 被引用次数：19 · 研究领域：Phytochemicals and Antioxidant Activities、Tannin, Tannase and Anticancer Activities、Ginkgo biloba and Cashew Applications

. Moreover, PMFs increased the contents of isobutyric acid and butyric acid, which were almost eliminated by antibiotic exposure. In conclusion, 5DN could alleviate antibiotic-related imbalance of intestinal oxidative stress, barrier function damage, intestinal flora disorders and the reduction of short-chain fatty acids (SCFAs), which lays a foundation for exploring safer and more effective ways to prevent or mitigate antibiotic-associated intestinal damage.