Predicting Microvascular Invasion in Hepatocellular Carcinoma Using CT-based Radiomics Model

作者：Tianyi Xia, Zheng-hao Zhou, Xiangpan Meng, Junhao Zha, Yu Qian, Wei-lang Wang, Yang Song, Yuancheng Wang, Tianyu Tang, Jun Xu, Tao Zhang, Xueying Long, Yun Liang, Wenbo Xiao, Shenghong Ju · 发表于：Radiology · 年份：2023 · DOI：10.1148/radiol.222729 · 被引用次数：239 · 研究领域：Radiomics and Machine Learning in Medical Imaging、Hepatocellular Carcinoma Treatment and Prognosis、Cholangiocarcinoma and Gallbladder Cancer Studies

Background Prediction of microvascular invasion (MVI) may help determine treatment strategies for hepatocellular carcinoma (HCC). Purpose To develop a radiomics approach for predicting MVI status based on preoperative multiphase CT images and to identify MVI-associated differentially expressed genes. Materials and Methods Patients with pathologically proven HCC from May 2012 to September 2020 were retrospectively included from four medical centers. Radiomics features were extracted from tumors and peritumor regions on preoperative registration or subtraction CT images. In the training set, these features were used to build five radiomics models via logistic regression after feature reduction. The models were tested using internal and external test sets against a pathologic reference standard to calculate area under the receiver operating characteristic curve (AUC). The optimal AUC radiomics model and clinical-radiologic characteristics were combined to build the hybrid model. The log-rank test was used in the outcome cohort (Kunming center) to analyze early recurrence-free survival and overall survival based on high versus low model-derived score. RNA sequencing data from The Cancer Image Archive were used for gene expression analysis. Results A total of 773 patients (median age, 59 years; IQR, 49–64 years; 633 men) were divided into the training set (n = 334), internal test set (n = 142), external test set (n = 141), outcome cohort (n = 121), and RNA sequencing analysis set ...