Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration

作者：Shukai Wang, Qian Hu, Zihao Chang, Yuqi Liu, Yuqi Liu, Ye Gao, Luo Xiaowei, Li‐Peng Zhou, Yinxin Chen, Yitong Cui, Zhaohui Wang, Baojin Wang, Ya Huang, Yue Liu, Yue Liu, Runping Liu, Lanzhen Zhang · 发表于：Food & Function · 年份：2023 · DOI：10.1039/d2fo03685a · 被引用次数：32 · 研究领域：Moringa oleifera research and applications、Immune cells in cancer、Mangiferin and Mango Extracts

studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4. The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.