Azithromycin Exposure Induces Transient Microbial Composition Shifts and Decreases the Airway Microbiota Resilience from Outdoor PM 2.5 Stress in Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled Trial

作者：Sisi Du, Lianhan Shang, Xiaohui Zou, Xiaoyan Deng, Aihua Sun, Shengrui Mu, Jiankang Zhao, Yimin Wang, Xiaoxuan Feng, Binbin Li, Chunlei Wang, Shuai Liu, Binghuai Lu, Yingmei Liu, Rongrong Zhang, Yigang Tong, Bin Cao · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.02066-22 · 被引用次数：13 · 研究领域：Gut microbiota and health、Chronic Obstructive Pulmonary Disease (COPD) Research、Asthma and respiratory diseases

The influence of antibiotic administration on the airway microbiota of healthy adults remains unknown. This study is a randomized, double-blind, placebo-controlled trial aiming to investigate the microbial shifts in airways after exposure to azithromycin among heathy adults. We find that azithromycin changes the airway microbial community composition of healthy adults and decreases the airway microbiota resilience against outdoor environmental stress. This study depicts the longitudinal recovery trajectory of airway microbiota after the antibiotic perturbation and may provide reference for appropriate antibiotic prescription.