Four-Component Ring-Opening Reaction of Pyrroles via C–N Bond Cleavage under Multiple Functions of Elemental Sulfur

作者：Zongkang Wang, Ye Wang, Yang Yuan, Yingge Gu, Yilin Zhu, Lijie Liu, Ziyi Zhuang, Lingkai Kong, Yanzhong Li · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c00945 · 被引用次数：9 · 研究领域：Sulfur-Based Synthesis Techniques、Synthesis of heterocyclic compounds、Multicomponent Synthesis of Heterocycles

We report a four-component ring-opening reaction of pyrroles via C-N bond cleavage. In this process, elemental sulfur is used as the sulfur source of thiazole and thioamide and the reductant of olefin. A series of benzothiazoles functionalized with thiopropionamides at the C2 position were synthesized using this method. A plausible reaction mechanism is proposed based on the concise control experiments.