Predictors of Lassa fever diagnosis in suspected cases reporting to health facilities in Nigeria

作者：Chinwe Lucia Ochu, Lorretta Ntoimo, Ikenna Onoh, Friday Okonofua, Martin Meremikwu, Sandra Mba, Akanimo Iniobong, Obinna Nwafor, Mahmood Dalhat, Cornelius Ohonsi, Chinedu Arinze, Ekpereonne Esu, Ehimario Igumbor, Chioma Dan-Nwafor, Elsie Ilori, Ifedayo Adetifa · 发表于：Scientific Reports · 年份：2023 · DOI：10.1038/s41598-023-33187-y · 被引用次数：15 · 研究领域：Viral Infections and Outbreaks Research、Disaster Response and Management、Viral Infections and Vectors

Lassa fever (LF) remains endemic in Nigeria with the country reporting the highest incidence and mortality globally. Recent national data suggests increasing incidence and expanding geographic spread. Predictors of LF case positivity in Nigeria have been sparsely studied. We thus sought to determine the sociodemographic and clinical determinants of LF positivity amongst suspected cases presenting to health facilities from 2018 to 2021. A secondary analysis of the national LF surveillance data between January 2018 and December 2021. Socio-demographic and clinical data of 20,027 suspected LF cases were analysed using frequencies and Chi-square statistics with significant p-value set at p < 0.05. The outcome variable was LF case status (positive or negative). Predictors of LF case positivity were assessed using multiple logistic regression models with 95% confidence intervals (CI). Case positivity rate (CPR) for the four years was 15.8% with higher odds of positivity among age group 40-49 years (aOR = 1.40; 95% CI 1.21-1.62), males (aOR = 1.11; 95% CI 1.03-1.20), those with formal education (aOR = 1.33; 95% CI 1.13-1.56), artisans (aOR = 1.70; 95% CI 1.28-2.27), religious leaders (aOR = 1.62; 95% CI 1.04-2.52), farmers (aOR = 1.48; 95% CI 1.21-1.81), and symptomatic individuals (aOR = 2.36; 95% CI 2.09-2.68). Being a health worker (aOR = 0.69; 95% CI 0.53-0.91), a teacher (aOR = 0.69; 95% CI 0.53-0.89) and cases reporting in the 3rd quarter (aOR = 0.79; 95% CI 0.69-0.92) had low...