Pathophysiological Links Between Obesity and Dementia

作者：David E. Wong Zhang, Vivian Tran, Antony Vinh, Quynh Nhu Dinh, Grant Raymond Drummond, Christopher Graeme Sobey, Maria Jelinic, T. Michael De Silva · 发表于：NeuroMolecular Medicine · 年份：2023 · DOI：10.1007/s12017-023-08746-1 · 被引用次数：34 · 研究领域：Regulation of Appetite and Obesity、Diet and metabolism studies、Dietary Effects on Health

Obesity is a major global health concern, with prevalence rates rapidly rising due to increased availability of highly processed foods rich in fats and/or sugars and technological advances promoting more sedentary behaviour. There is increasing evidence to suggest that obesity predisposes individuals to developing cognitive impairment and dementia. However, the relationship between the brain and the peripheral metabolic state is complex, and many of the underlying mechanisms of cognitive impairment in obesity are yet to be fully elucidated. To better understand the links between obesity and dementia, further work is required to determine pathological changes occurring in the brain during obesity. In this mini-review, we discuss the role of two pathological features of obesity (the gut-brain axis and systemic inflammation) and their potential contribution to dementia.