Sialic acid-targeting multi-functionalized silicon quantum dots for synergistic photodynamic and photothermal cancer therapy

作者：Fei Liu, Jiayi Lin, Yao Luo, Dong‐Lin Xie, Jiang Bian, Xiaobo Liu, Jun Yue · 发表于：Biomaterials Science · 年份：2023 · DOI：10.1039/d3bm00339f · 被引用次数：11 · 研究领域：Nanoplatforms for cancer theranostics、Ga2O3 and related materials、Carbon and Quantum Dots Applications

polydopamine-mediated chemistry. Upon irradiation with light of specific wavelengths, SiQDs@Ce6/PBA could generate high levels of reactive oxygen species (ROS) and trigger effective photo-to-thermal conversion. PBA-conjugation could not only increase the cellular uptake and transcellular transport capability of nanoparticles, but also enhance their tumor accumulation. In the presence of a 635 nm laser, SiQDs@Ce6/PBA was able to trigger intracellular ROS production, which further altered the mitochondrial membrane potential and promoted apoptosis of tumor cells. Finally, combined PDT/PTT treatments led to synergistically enhanced cancer cell killing and tumor-growth inhibition effects. This study demonstrates the surface engineering of silicon quantum dots for synergistic PDT/PTT cancer therapy.