Cerebral Small Vessel Disease Progression and the Risk of Dementia: A 14-Year Follow-Up Study

作者：Mina A. Jacob, Mengfei Cai, Vera van de Donk, Mayra I. Bergkamp, José P. Marques, David G. Norris, Roy P. C. Kessels, Jurgen A.H.R. Claassen, Marco Duering, Anil M. Tuladhar, Frank‐Erik de Leeuw · 发表于：American Journal of Psychiatry · 年份：2023 · DOI：10.1176/appi.ajp.20220380 · 被引用次数：55 · 研究领域：Dementia and Cognitive Impairment Research、Neurological Disease Mechanisms and Treatments、Acute Ischemic Stroke Management

OBJECTIVE: Cerebral small vessel disease (SVD) is considered the most important vascular contributor to cognitive decline and dementia, although a causal relation between its MRI markers and dementia still needs to be established. The authors investigated the relation between baseline SVD severity as well as SVD progression on MRI markers and incident dementia, by subtype, in individuals with sporadic SVD over a follow-up period of 14 years. METHODS: The study included 503 participants with sporadic SVD, and without dementia, from the prospective Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) study, with screening for baseline inclusion conducted in 2006. Follow-ups in 2011, 2015, and 2020 included cognitive assessments and MRI scans. Dementia was diagnosed according to DSM-5 criteria and stratified into Alzheimer's dementia and vascular dementia. RESULTS: Dementia as an endpoint was available for 498 participants (99.0%) and occurred in 108 participants (21.5%) (Alzheimer's dementia, N=38; vascular dementia, N=34; mixed-etiology Alzheimer's dementia/vascular dementia, N=26), with a median follow-up time of 13.2 years (interquartile range, 8.8-13.8). Higher baseline white matter hyperintensity (WMH) volume (hazard ratio=1.31 per 1-SD increase, 95% CI=1.02-1.67), presence of diffusion-weighted-imaging-positive lesions (hazard ratio=2.03, 95% CI=1.01-4.04), and higher peak width of skeletonized mean diffusivity (hazard ratio=1.24 per 1-SD i...