The chemokine CCL17 is a novel therapeutic target for cardiovascular aging

作者：Yang Zhang, Xiaoqiang Tang, Zeyuan Wang, Lun Wang, Zhangwei Chen, Juying Qian, Zhuang Tian, Shu-Yang Zhang · 发表于：Signal Transduction and Targeted Therapy · 年份：2023 · DOI：10.1038/s41392-023-01363-1 · 被引用次数：22 · 研究领域：Chemokine receptors and signaling、Neuroinflammation and Neurodegeneration Mechanisms、Immune cells in cancer

Aging results in higher susceptibility to age-related disease, especially cardiovascular disease, which has become a public health priority. 1 , 2 Recent studies have progressively unraveled the critical role of vasculature as a gatekeeper of life-span and health-span. 3 In this light, vascular rejuvenation is geroprotective. The circulating proteomic signature is tightly related to aging and aging-induced vascular diseases, 4 but drugs targeting circulating proteins are not available. Circulating cytokines and chemokines are essential immune components and regulate cardiovascular homeostasis and aging. 5 Modulating these factors is a potential strategy for treating cardiovascular aging.