Remote ischemic preconditioning improves spatial memory and sleep of young males during acute high-altitude exposure

作者：Yu Wu, Simin Zhou, Yaling Li, Pei Huang, Zhifeng Zhong, Huaping Dong, Huaijun Tian, Shuai Jiang, Jiaxin Xie, Peng Li · 发表于：Travel Medicine and Infectious Disease · 年份：2023 · DOI：10.1016/j.tmaid.2023.102576 · 被引用次数：15 · 研究领域：High Altitude and Hypoxia、Cardiac Ischemia and Reperfusion、Cardiac Arrest and Resuscitation

OBJECTIVE: The high-altitude hypoxia environment will cause poor acclimatization in a portion of the population. Remote ischemic preconditioning（RIPC）has been demonstrated to prevent cardiovascular and cerebrovascular diseases under ischemic or hypoxic conditions. However, its role in improving acclimatization and preventing acute mountain sickness (AMS) at high altitude has been undetermined. This study aims to estimate the effect of RIPC on acclimatization of individuals exposed to high altitude. METHODS: The project was designed as a randomized controlled trial with 82 healthy young males, who received RIPC training once a day for 7 consecutive days. Then they were transported by aircraft to a high altitude (3680 m) and examined for 6 days. Lake Louise Score(LLS) of AMS, physiological index, self-reported sleep pattern, and Pittsburgh Sleep Quality Index（PSQI）score were applied to assess the acclimatization to the high altitude. Five neurobehavioral tests were conducted to assess cognitive function. RESULTS: The result showed that the RIPC group had a significantly lower AMSscore than the control group (2.43 ± 1.58 vs 3.29 ± 2.03, respectively; adjusted mean difference-0.84, 95% confidence interval-1.61 to -0.06, P = 0.036). and there was no significant difference in AMS incidence between the two groups (25.0% vs 28.57%, P = 0.555). The RIPC group performed better than the control group in spatial memory span score (11[9-12] vs 10[7.5-11], P=0.025) and the passing digit (7...