Drug-induced tooth discoloration: An analysis of the US food and drug administration adverse event reporting system

作者：Jun Wang, Dongna Zou, Yuchao Li, Pingping Liu, Chenyu Guo · 发表于：Frontiers in Pharmacology · 年份：2023 · DOI：10.3389/fphar.2023.1161728 · 被引用次数：25 · 研究领域：Drug-Induced Adverse Reactions、Dental Anxiety and Anesthesia Techniques、Oral and gingival health research

Background: Certain drugs can cause intrinsic or extrinsic tooth discoloration, which is not only a clinical issue but also an esthetic problem. However, limited investigations have focused on drug-induced tooth discoloration. The present work aimed to determine the drugs causing tooth discoloration and to estimate their risks of causing tooth discoloration. Methods: An observational, retrospective, and pharmacovigilance analysis was conducted, in which we extracted adverse event (AE) reports involving tooth discoloration by using the data of the US Food and Drug Administration’s Adverse Event Reporting System (FAERS) from the first quarter (Q1) of 2004 to the third quarter (Q3) of 2021. Disproportionality analyses were performed to examine risk signals for tooth discoloration and determine the drugs inducing tooth discoloration. Results: Based on predefined inclusion criteria, 1188 AE reports involving 302 suspected drugs were identified. After data mining, 25 drugs generated positive risk signals for tooth discoloration, of which 10 were anti-infectives for systemic use. The top reported drug was tetracycline ( n = 106), followed by salmeterol and fluticasone ( n = 68), amoxicillin ( n = 60), chlorhexidine ( n = 54), and nicotine ( n = 52). Cetylpyridinium (PRR = 472.2, ROR = 502.5), tetracycline (PRR = 220.4, ROR = 277), stannous fluoride (PRR = 254.3, ROR = 262.8), hydrogen peroxide (PRR = 240.0, ROR = 247.6), and chlorhexidine (PRR = 107.0, ROR = 108.4) showed stronger a...