Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications

作者：Yang Zhu, Yaxin Liao, Jianhua Zou, Junjie Cheng, Yuanbo Pan, Lisen Lin, Xiaoyuan Chen · 发表于：Small · 年份：2023 · DOI：10.1002/smll.202300750 · 被引用次数：95 · 研究领域：Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications、Advanced biosensing and bioanalysis techniques

Nanomaterials with enzyme-mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the rapid development of nanotechnology and characterization techniques, single atom nanozymes (SAzymes) with atomically dispersed active sites, well-defined electronic and geometric structures, tunable coordination environment, and maximum metal atom utilization are developed and exploited. With superior catalytic performance and selectivity, SAzymes have made impressive progress in biomedical applications and are expected to bridge the gap between artificial nanozymes and natural enzymes. Herein, the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications are systematically summarized. Their biomedical applications in cancer therapy, oxidative stress cytoprotection, antibacterial therapy, and biosensing are discussed in depth. Furthermore, to appreciate these advances, the main challenges, and prospects for the future development of SAzymes are also outlined and highlighted in this review.