Manganese supplementation of orthopedic implants: a new strategy for enhancing integrin-mediated cellular responses

作者：Kai Li, Shiwei Liu, Jieping Li, Deliang Yi, Dandan Shao, Tao Hu, Xuebin Zheng · 发表于：Biomaterials Science · 年份：2023 · DOI：10.1039/d2bm02165j · 被引用次数：9 · 研究领域：Bone Tissue Engineering Materials、Orthopaedic implants and arthroplasty、Polymer Surface Interaction Studies

nanocoating enhanced cell adhesion with the long stretched structure of actin fibers and extensive formation of vinculin focal adhesion spots and upregulated the levels of alkaline phosphatase and osteocalcin activities. Therefore, Mn supplementation of orthopedic implants may be a promising way to improve osteogenesis at the implant surface.