Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts

作者：Nana Kwame Ampomah, Flavia Teles, Lynn M. Martin, Jiayun Lu, Devin C. Koestler, Karl T. Kelsey, James D. Beck, Elizabeth A. Platz, Dominique S. Michaud · 发表于：JNCI Cancer Spectrum · 年份：2023 · DOI：10.1093/jncics/pkad029 · 被引用次数：9 · 研究领域：Oral microbiology and periodontitis research、Salivary Gland Disorders and Functions、Oral and gingival health research

BACKGROUND: Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers. METHODS: Incident lung cancer cases (n = 192) and matched controls (n = 192) were selected from participants of the CLUE I and CLUE II cohorts. Archived serum samples collected from participants in 1974 (in CLUE I) were analyzed using immunoblotting for immunoglobulin G (IgG) antibody levels to 13 bacteria of the periodontium. Associations between antibody levels and lung cancer were estimated using conditional logistic regression. RESULTS: Most of the periodontal bacterial antibodies measured were inversely associated with lung cancer risk; of these, 3 were statistically significant (Prevotellaintermedia, Actinomyces naeslundii, and Veillonella parvula). A statistically significant positive association was observed for one of the Porphyromonas gingivalis strains after adjusting for P. intermedia. The sum of the logarithm of antibodies against the 13 measured bacteria was inversely associated with risk of lung cancer when the analysis was restricted to a longer follow-up (31-44 years after blood collection, highest vs lowest quartile: odds ratio = 0.26, 95% confidence interval = 0.08 to 0.84). CONCLUSIONS: Findings from this study highlight the complexity of using serum IgG antibod...