Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice

作者：Jian Ding, Ming Xu, Wei Du, Zhiqiang Fang, Hao Xu, Jingjing Liu, Ping Song, Xu Chen, Zhiwen Li, Zhen‐Sheng Yue, Yu‐Wei Ling, Juanli Duan, Kaishan Tao, Fei He, Lin Wang · 发表于：International Journal of Biological Sciences · 年份：2023 · DOI：10.7150/ijbs.80122 · 被引用次数：27 · 研究领域：MicroRNA in disease regulation、Liver Disease Diagnosis and Treatment、Circular RNAs in diseases

Combined, macrophage RBP-J promotes the progression of NAFLD at least partially through regulating the expression of pro-inflammatory cytokines IL1β and TNFα. Infusion of exosomes loaded with RBP-J decoy ODNs might be a promising therapy to treat NAFLD.