Regioselective Reaction of 2-Indolylmethanols with Enamides

作者：Yu‐Ting Tian, Dongqing He, Limei Gao, Yu Zou, Xiaoshuang Liu, Qiang Wang, Enxiang Liang, Yongsheng Zheng · 发表于：Molecules · 年份：2023 · DOI：10.3390/molecules28083341 · 被引用次数：2 · 研究领域：Synthesis of Indole Derivatives、Chemical Synthesis and Reactions、Asymmetric Synthesis and Catalysis

A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl3 as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.