The Consistence of Dynamic Contrast‐Enhanced MRI and Filter‐Exchange Imaging in Measuring Water Exchange Across the Blood–Brain Barrier in High‐Grade Glioma

作者：Zejun Wang, Bao Wang, Zhaoqing Li, Guangxu Han, Cheng Meng, Bingjie Jiao, Kaiyue Guo, Yi‐Cheng Hsu, Yi Sun, Yingchao Liu, Ruiliang Bai · 发表于：Journal of Magnetic Resonance Imaging · 年份：2023 · DOI：10.1002/jmri.28729 · 被引用次数：7 · 研究领域：Advanced MRI Techniques and Applications、MRI in cancer diagnosis、Glioma Diagnosis and Treatment

Background Water exchange across blood–brain barrier (BBB) (WEX BBB ) is an emerging biomarker of BBB dysfunction with potential applications in many brain diseases. Several MRI methods have been proposed to measure WEX BBB , but evidence remains scarce whether different methods can produce comparable WEX BBB . Purpose To explore whether dynamic contrast‐enhanced (DCE)‐MRI and vascular water exchange imaging (VEXI) could produce comparable WEX BBB in high‐grade glioma (HGG) patients. Study Type Prospective cross‐sectional. Subjects 13 HGG patients (58.4 ± 9.4 years, 9 females, 4 WHO III and 9 WHO IV). Field Strength/Sequence A 3 T, spoiled gradient‐recalled‐echo DCE‐MRI and VEXI containing two pulsed‐gradient spin‐echo blocks separated by a mixing block. Assessments The enhanced tumor and contralateral normal‐appearing white matter (cNAWM) volume‐of‐interests (VOIs) were drew by two neuroradiologists. And whole‐brain NAWM and normal‐appearing gray matter (NAGM) without tumor‐affected regions were segmented by automated segmentation algorithm in FSL. Statistical Tests Student's t ‐test was used to evaluate parameters difference between cNAWM and tumor, NAGM and NAWM, respectively. The correlation between vascular water efflux rate constant ( k bo ) from DCE‐MRI and apparent exchange rate across BBB (AXR BBB ) from VEXI was evaluated by Pearson correlation. P < 0.05 was considered statistically significant. Results Compared with cNAWM, both k bo and AXR BBB were significantl...