SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection

作者：Yue Qu, Aline Haas de Mello, Dorothea R. Morris, Yava Jones‐Hall, Teodora Ivanciuc, Rachel A. Sattler, Slobodan Paessler, Vineet D. Menachery, Robert Garofalo, Antonella Casola · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.00378-23 · 被引用次数：59 · 研究领域：Genomics, phytochemicals, and oxidative stress、Vitamin C and Antioxidants Research、Sulfur Compounds in Biology

gene show increased clinical signs of disease and lung pathology when infected with a mouse-adapted strain of SARS-CoV-2. Overall, this study provides a mechanistic explanation for the observed unbalanced pro-oxidative response in SARS-CoV-2 infections and suggests that therapeutic strategies for COVID-19 may consider the use of pharmacologic agents that are known to boost the expression levels of cellular NRF2.